AWS offers OpenFold3 research preview through SageMaker JumpStart

AWS says customers can deploy OpenFold3-preview through SageMaker JumpStart to predict the three-dimensional structures of proteins, DNA, RNA, small molecules and their complexes. The open source model runs in an AWS-maintained container within the customer's account. The service queues long-running prediction jobs, writes results to Amazon S3 and supports scaling endpoints to zero when idle. Network isolation prevents the endpoint from calling external servers for sequence alignments, which supply evolutionary information that can improve predictions; customers must provide those alignments themselves. The developers classify the model as a research preview. AWS cautions that its demonstrated prediction of a well-studied complex is a workflow example, rather than an accuracy benchmark for novel targets.