# DeepMind's AlphaGenome 2 predicts DNA variant effects by cell type

_Published Thursday, November 12, 2026 at 4:46 PM EST · Science, AI · Latest · Tier 2 — Notable_

Google DeepMind announced AlphaGenome 2, a model that predicts how non-coding DNA affects gene activity in specific cell types. Nature reported that it replicated aspects of an inflammatory bowel disease finding in 30 minutes; the researcher who led the original work said those experiments took a year and a half.

Described in a preprint, the model was trained on measurements from more than 100 million cells across 68 tissues. Its predecessor did not specify the precise cell type in which a variant would act.

Researchers can also supply new single-cell gene-activity data to generate predictions beyond the 637 human and 311 mouse cell types used in training.

## Sources

- [Nature](https://www.nature.com/articles/d41586-026-03673-0)

---
Canonical: https://techandbusiness.org/newswire/f56RABuffro6GdffvisNxj
Published: 2026-11-12T21:46:24.192Z
Story chronology: 2026-11-11T00:00:00.000Z
Retrieved: 2026-11-12T23:40:46.917Z
Publisher: Tech & Business (techandbusiness.org)