# MIT team reports angstrom-scale localization with single-laser U-STORM imaging

_Sunday, August 2, 2026 at 2:00 PM EDT · Science · Latest · Tier 2 — Notable_

![MIT team reports angstrom-scale localization with single-laser U-STORM imaging — Primary](https://scx2.b-cdn.net/gfx/news/hires/2026/researchers-break-diff.jpg)

Researchers in Sam Peng's lab at MIT and the Broad Institute of MIT and Harvard have developed a super-resolution method that localizes molecular structures at angstrom-level precision using a simplified imaging process, phys.org reported, citing an open-access Nature Nanotechnology paper.

The approach, called U-STORM, uses upconverting nanoparticles that can blink indefinitely under illumination, unlike traditional dyes that fade quickly. Phys.org said the method reaches localization precision of 0.6 Å after more than 88,000 localization events from the same particle, three orders of magnitude beyond nanometer-scale limits of standard fluorescent dyes, while using one laser.

An open-access description by Saptarshi Mandal and colleagues was published in Nature Nanotechnology (DOI: 10.1038/s41565-026-02233-x). The work is positioned as a way to visualize molecular structures with fewer experimental constraints than multi-laser dye systems.

## Sources

- [phys.org](https://phys.org/news/2026-07-microscopy-method-angstrom-scale-localization.html)

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