Science
Mayo Clinic researchers discover vasopressin-independent kidney water pathway
Image: Primary Mayo Clinic researchers have discovered a previously unknown pathway that allows kidneys to concentrate urine independently of vasopressin, the hormone long considered the primary regulator of water retention, SciTechDaily reports. The finding, published 16 June 2026 in the Journal of Clinical Investigation, emerged during research into polycystic kidney disease (PKD) and could lead to new treatments that reduce side effects of the only approved PKD drug, tolvaptan.
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