OHSU study uncovers internal cell 'trade winds' that drive movement and repair

Scientists at Oregon Health and Science University have uncovered a system of internal fluid flows that push essential proteins to the front of cells. The discovery, published in Nature Communications, shows that cells actively generate targeted streams rather than relying solely on random diffusion for protein transport. Researchers describe the mechanism as critical to cell migration, cancer spread and wound healing. The finding originated from an unexpected observation during a neurobiology course at the Marine Biological Laboratory, according to co-corresponding Experiments showed the cells create directional currents, compared to atmospheric rivers, inside a specialized compartment at the front separated The Galbraiths said the mechanism may explain why certain cancer cells migrate aggressively. The project drew on collaborators at Janelia Research Campus and received support from the National Institute of General Medical Sciences and other organizations.